Oxidative damage to mitochondria is mediated by the Ca(2+)-dependent inner-membrane permeability transition.

@article{Takeyama1993OxidativeDT,
  title={Oxidative damage to mitochondria is mediated by the Ca(2+)-dependent inner-membrane permeability transition.},
  author={Naoshi Takeyama and Noriaki Matsuo and Takaya Tanaka},
  journal={The Biochemical journal},
  year={1993},
  volume={294 ( Pt 3)},
  pages={719-25}
}
The ability of O2 metabolites derived from the xanthine-xanthine oxidase system to inhibit mitochondrial function was examined using freshly isolated rat liver mitochondria. Under 2,4-dinitrophenol-uncoupled conditions, mitochondria exposed to free radicals exhibited a significant decrease in O2 consumption supported by NAD(+)-linked substrates, but showed almost no change in O2 consumption in the presence of succinate and ascorbate. Oxidative stress caused the loss of intramitochondrial… CONTINUE READING