Oxidative damage to DNA: do we have a reliable biomarker?

  title={Oxidative damage to DNA: do we have a reliable biomarker?},
  author={Andrew R Collins and M{\'a}ria Du{\vs}insk{\'a} and Catherine M Gedik and Rudolf {\vS}tětina},
  journal={Environmental Health Perspectives},
  pages={465 - 469}
Oxidized bases in DNA can be measured directly by high-performance liquid chromatography (HPLC). 7,8-Dihydro-8-oxo-guanine (8-OHgua), as the most abundant oxidation product, is often regarded as an indicator of oxidative stress. Estimates of endogenous 8-OHgua levels in human lymphocyte DNA are between 2 and 8 for every 10(5) unaltered bases--a high frequency in view of the potential mutagenicity of this base alteration and of the presence of an effective base excision repair pathway in… CONTINUE READING


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Evidence for two DNA repair enzymes for 8hydroxyguanine ( 7 , 8dihydro8oxoguanine ) in human cells

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