Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.

@article{OHagan2011OxidativeDT,
  title={Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.},
  author={Heather M O'Hagan and Wei Wang and Subhojit Sen and Christina E DeStefano Shields and Stella Suyong Lee and Yang Zhang and Eriko G. Clements and Yi Cai and Leander van Neste and Hariharan Easwaran and Robert Anthony Casero and Cynthia L Sears and Stephen B. Baylin},
  journal={Cancer cell},
  year={2011},
  volume={20 5},
  pages={606-19}
}
Cancer cells simultaneously harbor global losses and gains in DNA methylation. We demonstrate that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin. DNMT1 becomes part of a complex(es) containing DNMT3B and members of the polycomb repressive complex 4. Hydrogen peroxide treatment causes relocalization of these proteins from non-GC-rich to GC-rich areas. Key components are similarly enriched at gene promoters in an in… CONTINUE READING
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