Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases.

@article{Choi2006OxidativeDO,
  title={Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases.},
  author={Joungil Choi and M. Cameron Sullards and James A. Olzmann and Howard D. Rees and Susan T. Weintraub and David E Bostwick and Marla Gearing and Allan I. Levey and Lih-Shen Chin and Lian Li},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 16},
  pages={10816-24}
}
Mutations in DJ-1 cause an autosomal recessive, early onset familial form of Parkinson disease (PD). However, little is presently known about the role of DJ-1 in the more common sporadic form of PD and in other age-related neurodegenerative diseases, such as Alzheimer disease (AD). Here we report that DJ-1 is oxidatively damaged in the brains of patients with idiopathic PD and AD. By using a combination of two-dimensional gel electrophoresis and mass spectrometry, we have identified 10… CONTINUE READING
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