Oxidative damage in nucleic acids and Parkinson's disease.

  title={Oxidative damage in nucleic acids and Parkinson's disease.},
  author={Yusaku Nakabeppu and Daisuke Tsuchimoto and Hiroo Yamaguchi and Kunihiko Sakumi},
  journal={Journal of neuroscience research},
  volume={85 5},
Oxidative DNA lesions, such as 8-oxoguanine (8-oxoG), accumulate in nuclear and mitochondrial genomes during aging, and such accumulation can increase dramatically in patients with Parkinson's disease (PD). To counteract oxidative damage to nucleic acids, human and rodents are equipped with three distinct enzymes. One of these, MTH1, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-2'-deoxyguanosine triphosphate and 2-hydroxy-2'-deoxyadenosine triphosphate, to their… CONTINUE READING