Oxidative damage and induced mutations in m13mp2 phage DNA exposed to N-nitrosopyrrolidine with UVA radiation.

@article{ArimotoKobayashi2000OxidativeDA,
  title={Oxidative damage and induced mutations in m13mp2 phage DNA exposed to N-nitrosopyrrolidine with UVA radiation.},
  author={Sakae Arimoto-Kobayashi and N Anma and Yuko Yoshinaga and Thierry Douki and Jean Cadet and Hikoya Hayatsu},
  journal={Mutagenesis},
  year={2000},
  volume={15 6},
  pages={473-7}
}
N:-Nitrosopyrrolidine (NPYR) is carcinogenic in rodents and undergoes alpha-hydroxylation upon microsomal CYP450 metabolism, giving rise to mutations. Previously, we reported the direct mutagenicity of NPYR, under ultraviolet A (UVA) irradiation, towards Salmonella typhimurium and phage M13mp2. In the present study, we measured the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in a replicative form of M13mp2 DNA exposed to NPYR plus UVA. Formation of 5-hydroxy-2'-deoxycytidine in… CONTINUE READING

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