Oxidative damage and genotoxicity biomarkers in transfused and untransfused thalassemic subjects.

@article{Ferro2012OxidativeDA,
  title={Oxidative damage and genotoxicity biomarkers in transfused and untransfused thalassemic subjects.},
  author={Elisa Ferro and Giuseppa Visalli and Rosa Civa and Maria Angela La Rosa and Gaetano Randazzo Papa and Barbara Baluce and Domenico Giuseppe D'Ascola and Basilia Piraino and Carmelo Salpietro and Angela Di Pietro},
  journal={Free radical biology & medicine},
  year={2012},
  volume={53 10},
  pages={
          1829-37
        }
}
Chronic anemia and tissue hypoxia increase intestinal iron absorption and mitochondrial impairment in thalassemic patients. Regular blood transfusions improve hemoglobin levels but determine an iron overload that induces reactive oxygen species (ROS) overproduction. The aim of this study was to assess cellular oxidative damage by detection of ROS, lipid peroxidation, 8-oxo-dG, and mitochondrial transmembrane potential (Δψ(m)) in transfused and untransfused thalassemic patients. We have also… CONTINUE READING
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