Oxidative damage–induced inflammation initiates age-related macular degeneration

@article{Hollyfield2008OxidativeDI,
  title={Oxidative damage–induced inflammation initiates age-related macular degeneration},
  author={J. Hollyfield and V. Bonilha and M. Rayborn and Xiaoping Yang and K. Shadrach and L. Lu and R. Ufret and R. G. Salomon and V. Perez},
  journal={Nature Medicine},
  year={2008},
  volume={14},
  pages={194-198}
}
Oxidative damage and inflammation are postulated to be involved in age-related macular degeneration (AMD). However, the molecular signal(s) linking oxidation to inflammation in this late-onset disease is unknown. Here we describe AMD-like lesions in mice after immunization with mouse serum albumin adducted with carboxyethylpyrrole, a unique oxidation fragment of docosahexaenoic acid that has previously been found adducting proteins in drusen from AMD donor eye tissues and in plasma samples from… Expand
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  • 2012
TLDR
Regulating ROS in the RPE by modulating antioxidant systems or neutralizing OSEs through an appropriate innate immune response are potential modalities to treat or prevent early AMD. Expand
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The data indicating that the complement pathway is involved in AMD are unequivocal and strongly indicate that AMD has a genetic component and that inflammation plays an important role in the pathology of AMD. Expand
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The data suggest that disruption of Nfe2l2 gene increased the vulnerability of outer retina to age-related degeneration and deregulated autophagy is likely a mechanistic link between oxidative injury and inflammation. Expand
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