Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q(10).

@article{Lim2006OxidativeBI,
  title={Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q(10).},
  author={Su Chi Lim and Hwee Huang Tan and Siew Kheng Goh and Tavintharan Subramaniam and Chee Fang Sum and I. K. S. Tan and Bee Lan Lee and Choon Nam Ong},
  journal={Diabetic medicine : a journal of the British Diabetic Association},
  year={2006},
  volume={23 12},
  pages={1344-9}
}
AIM Individuals with diabetes and prediabetes are at risk of vascular injury. However, the exact mechanisms are unclear. The mitochondria mobile electron carrier coenzyme Q(10) (CoQ(10)) is a potent lipophilic antioxidant. We hypothesize that oxidative stress, detectable as changes in plasma CoQ(10) concentrations and composition, plays an important role in vascular disease in diabetes. METHODS We measured plasma CoQ(10) concentrations (including reduced ubiquinol and oxidized ubiquinone… CONTINUE READING
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