Oxidative bioactivation of abacavir in subcellular fractions of human antigen presenting cells.

@article{Bell2013OxidativeBO,
  title={Oxidative bioactivation of abacavir in subcellular fractions of human antigen presenting cells.},
  author={Catherine C. Bell and Anahi Santoyo Castelazo and Emma L Yang and James L. Maggs and Rosalind Jenkins and Jonathan D. Tugwood and Paul M O'neill and Dean J Naisbitt and Brian Kevin Park},
  journal={Chemical research in toxicology},
  year={2013},
  volume={26 7},
  pages={1064-72}
}
Human exposure to abacavir, a primary alcohol antiretroviral, is associated with the development of immunological drug reactions in individuals carrying the HLA risk allele B*57:01. Interaction of abacavir with antigen presenting cells results in cell activation through an Hsp70-mediated Toll-like receptor pathway and the provision of T-cell antigenic… CONTINUE READING