Oxidative autoactivation of latent collagenase by human neutrophils.

  title={Oxidative autoactivation of latent collagenase by human neutrophils.},
  author={Stephen J Weiss and G J Peppin and X Ortiz and Cliff Ragsdale and Samuel T Test},
  volume={227 4688},
The pathological destruction of collagen plays a key role in the development of inflammatory disease states affecting every organ system in the human body. Neutrophils localized at inflammatory sites can potentially degrade collagen by releasing a metalloenzyme, collagenase, which is stored in a latent inactive form. Triggered human neutrophils were shown to release and simultaneously activate their latent collagenase. The activation of the latent enzyme was coupled to an oxidative process that… CONTINUE READING