Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor.

@article{Fischer2004OxidativeAO,
  title={Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor.},
  author={Oliver Martin Fischer and Stefan Willi Hart and Andreas Gschwind and Norbert Prenzel and Axel A Ullrich},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 12},
  pages={5172-83}
}
Mammalian cells respond to environmental stress by activating a variety of protein kinases critical for cellular signal transmission, such as the epidermal growth factor receptor (EGFR) tyrosine kinase and different members of the mitogen-activated protein kinase (MAPK) family. EGFR activation by stress stimuli was previously thought to occur independently of stimulation by extracellular ligands. Here, we provide evidence that osmotic and oxidative stresses induce a metalloprotease activity… CONTINUE READING
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