Oxidative and nitrosative stress pathways in the brain of socially isolated adult male rats demonstrating depressive- and anxiety-like symptoms

@article{Filipovi2016OxidativeAN,
  title={Oxidative and nitrosative stress pathways in the brain of socially isolated adult male rats demonstrating depressive- and anxiety-like symptoms},
  author={Dragana Filipovi{\'c} and Nevena Todorovi{\'c} and Rick Eugene Bernardi and Peter Gass},
  journal={Brain Structure and Function},
  year={2016},
  volume={222},
  pages={1-20}
}
Various stressors may disrupt the redox homeostasis of an organism by causing oxidative and nitrosative stress that may activate stressor-specific pathways and provoke specific responses. Chronic social isolation (CSIS) represents a mild chronic stress that evokes a variety of neurobehavioral changes in rats similar to those observed in people with psychiatric disorders, including depression. Most rodent studies have focused on the effect of social isolation during weaning or adolescence, while… CONTINUE READING