Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response.

@article{Wang2007OxidativeAN,
  title={Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response.},
  author={Gangduo Wang and Ping Cai and G. A. Shakeel Ansari and Mahjabeen Khan},
  journal={Toxicology},
  year={2007},
  volume={229 3},
  pages={186-93}
}
Reactive oxygen and nitrogen species (RONS) are implicated in the pathogenesis of several autoimmune diseases. Also, increased lipid peroxidation and protein nitration are reported in systemic autoimmune diseases. Lipid peroxidation-derived aldehydes (LPDAs) such as malondialdehyde (MDA) and 4-hydroxynonenal (HNE) are highly reactive and bind proteins covalently, but their potential to elicit an autoimmune response and contribution to disease pathogenesis remain unclear. Similarly, nitration of… CONTINUE READING