Oxidative and nitrosative stress in acute renal ischemia.

@article{Noiri2001OxidativeAN,
  title={Oxidative and nitrosative stress in acute renal ischemia.},
  author={Eisei Noiri and Atsunori Nakao and Kenzo Uchida and Hirokazu Tsukahara and Minoru Horie Ohno and Toshiro Fujita and Simon Brodsky and Michael S. Goligorsky},
  journal={American journal of physiology. Renal physiology},
  year={2001},
  volume={281 5},
  pages={
          F948-57
        }
}
Generation of reactive oxygen species and nitric oxide in hypoxia-reperfusion injury may form a cytotoxic metabolite, peroxynitrite, which is capable of causing lipid peroxidation and DNA damage. This study was designed to examine the contribution of oxidative and nitrosative stress to the renal damage in ischemic acute renal failure (iARF). iARF was initiated in rats by 45-min renal artery clamping. This resulted in lipid peroxidation, DNA damage, and nitrotyrosine modification confirmed both… CONTINUE READING

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