Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation.

@article{Kawanishi2006OxidativeAN,
  title={Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation.},
  author={Shosuke Kawanishi and Yusuke Hiraku},
  journal={Antioxidants & redox signaling},
  year={2006},
  volume={8 5-6},
  pages={1047-58}
}
Reactive oxygen and nitrogen species are known to participate in a wide variety of human diseases. Oxidative DNAdamage is involved in chemical carcinogenesis and aging. Monocyclic chemicals induce mainly oxidative DNAdamage, whereas polycyclic chemicals can induce oxidative DNA damage in addition to DNA adduct formation. Recently, chronic infection and inflammation have been recognized as important factors for carcinogenesis. Nitrative DNA damage as well as oxidative DNA damage is induced in… CONTINUE READING

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