Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

@article{Maher2007OxidativeAE,
  title={Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway},
  author={J. Maher and M. Z. Dieter and L. Aleksunes and A. Slitt and Grace Guo and Y. Tanaka and G. Scheffer and J. Chan and J. Manautou and Y. Chen and T. Dalton and M. Yamamoto and C. Klaassen},
  journal={Hepatology},
  year={2007},
  volume={46}
}
  • J. Maher, M. Z. Dieter, +10 authors C. Klaassen
  • Published 2007
  • Biology, Medicine
  • Hepatology
    • Multidrug resistance–associated proteins (Mrps) are adenosine triphosphate–dependent transporters that efflux chemicals out of cells. In the liver, Mrp2 transports bilirubin‐glucuronide, glutathione (GSH), and drug conjugates into bile, whereas Mrp3 and Mrp4 efflux these entities into blood. The purpose of this study was to determine whether oxidative conditions (that is, the disruption of hepatic GSH synthesis) or the administration of nuclear factor‐E2–related factor‐2 (Nrf2) activators… CONTINUE READING
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