Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway

@article{Maher2007OxidativeAE,
  title={Oxidative and electrophilic stress induces multidrug resistance–associated protein transporters via the nuclear factor‐E2–related factor‐2 transcriptional pathway},
  author={J. Maher and M. Z. Dieter and L. Aleksunes and A. Slitt and Grace Guo and Y. Tanaka and G. Scheffer and J. Chan and J. Manautou and Y. Chen and T. Dalton and M. Yamamoto and C. Klaassen},
  journal={Hepatology},
  year={2007},
  volume={46}
}
  • J. Maher, M. Z. Dieter, +10 authors C. Klaassen
  • Published 2007
  • Biology, Medicine
  • Hepatology
  • Multidrug resistance–associated proteins (Mrps) are adenosine triphosphate–dependent transporters that efflux chemicals out of cells. In the liver, Mrp2 transports bilirubin‐glucuronide, glutathione (GSH), and drug conjugates into bile, whereas Mrp3 and Mrp4 efflux these entities into blood. The purpose of this study was to determine whether oxidative conditions (that is, the disruption of hepatic GSH synthesis) or the administration of nuclear factor‐E2–related factor‐2 (Nrf2) activators… CONTINUE READING
    280 Citations
    Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver
    • 100
    • PDF
    Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver.
    • 280
    Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression.
    • 79
    Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice.
    • 69
    • PDF
    Coordinated Regulation of Hepatic Phase I and II Drug-Metabolizing Genes and Transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-Null Mice
    • 181
    • PDF
    Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine.
    • 44
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 66 REFERENCES
    Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene.
    • 208
    Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages*
    • 1,263
    • PDF
    Coordinated expression of multidrug resistance-associated proteins (Mrps) in mouse liver during toxicant-induced injury.
    • 79
    • PDF
    Activation of hepatic Nrf2 in vivo by acetaminophen in CD‐1 mice
    • 165