Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo.

@article{Jones2010OxidativeAC,
  title={Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo.},
  author={Huw S. Jones and Grace H. Panter and Thomas H. Hutchinson and James Kevin Chipman},
  journal={Zebrafish},
  year={2010},
  volume={7 1},
  pages={23-30}
}
As zebrafish larvae are being increasingly applied to toxicity testing, there is a need to understand the potential for xenobiotic metabolism by these early life-stage organisms. The expression of genes similar to mammalian cytochromes P450 (CYP) 2B6, CYP3A5, and UDP-glucuronosyl transferase (UGT) 1A1, as well as the zebrafish CYP1A was assessed across embryonic development. Activities toward 7-ethoxyresorufin O-deethylase (EROD assay), 7-ethoxycoumarin O-deethylase (ECOD assay), and… CONTINUE READING