Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma.

@article{AlHarbi2015OxidativeAI,
  title={Oxidative airway inflammation leads to systemic and vascular oxidative stress in a murine model of allergic asthma.},
  author={Naif O. Al-Harbi and A Nadeem and Mohamed M. Al-Harbi and Faisal Imam and O A Al-shabanah and Sheikh Fayaz Ahmad and Mohamed Mohamed Sayed-Ahmed and Saleh Abd El-Rahman Bahashwan},
  journal={International immunopharmacology},
  year={2015},
  volume={26 1},
  pages={237-45}
}
Oxidant-antioxidant imbalance plays an important role in repeated cycles of airway inflammation observed in asthma. It is when reactive oxygen species (ROS) overwhelm antioxidant defenses that a severe inflammatory state becomes apparent and may impact vasculature. Several studies have shown an association between airway inflammation and cardiovascular complications; however so far none has investigated the link between airway oxidative stress and systemic/vascular oxidative stress in a murine… CONTINUE READING
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