Oxidative Stress in Chagas Disease

  title={Oxidative Stress in Chagas Disease},
  author={Shivali Gupta and Jian-jun Wen and Nisha Jain Garg},
  booktitle={Interdisciplinary perspectives on infectious diseases},
There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress induced injuries that may contribute to disease progression. Trypanosoma cruzi invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) during acute infection. Mitochondria are proposed to be the major source of ROS in chronic chagasic hearts. However, it has not been established yet, whether… CONTINUE READING


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