Oxidative Stress by Tartrazine in the Testis of Wistar Rats

@article{Visweswaran2012OxidativeSB,
  title={Oxidative Stress by Tartrazine in the Testis of Wistar Rats},
  author={Bhadri Visweswaran and Gunasekaran Krishnamoorthy},
  journal={IOSR Journal of Pharmacy and Biological Sciences},
  year={2012},
  volume={2},
  pages={44-47}
}
The aim is to study the effect of Tartrazine (E102) - synthetic food colour - on the antioxidant status of testis of Wistar rats. Twelve male Wistar rats were grouped into 2 groups of six each - Control and Tartrazine-treated groups. Control group was orally administered with water alone while the experimental group was orally administered with tartrazine dissolved in water. The treatment was carried out for 60 days and the activities of antioxidant enzymes - superoxide dismutase (SOD… 
View via Publisher
iosrjournals.org
29 Citations
Highly Influential Citations
1
Background Citations
15
Methods Citations
1
Results Citations
4

Figures from this paper

29 Citations

Assessment of a sub-chronic consumption of tartrazine ( E 102 ) on sperm and oxidative stress features in Wistar rat
TLDR
The results revealed that subchronic exposure to tartrazine could be extremely harmful to the reproductive function, and it is mandatory to raise the awareness of health issue related to this dye.
Effect of Tartrazine on Thyroid Gland of Male Rat and Ameliorating Role of Curcumin (Histological and Immunohistochemical Study)
TLDR
Curcumin have a relevant protective role against tartrazine-induced thyroid gland damage and Administration of curcumin showed improvement in the biochemical parameters and thyroid structure than in recovery group.
Prevention of toxic effects of orally administered tartrazine by crocin in Wistar rats
TLDR
Tartrazine consumption elicited tissue injury via lipid peroxidation, and crocin ameliorated oxidative injury by its antioxidant and free radical scavenger properties.
The Potential Therapeutic Effect of Ferulic Acid in Mitigating Oxidative Stress Induced by γ-Irradiation in Male Rats
TLDR
FA exhibited curative effect against radiation induced testicular damage and significantly reversed OS effects of γ-rays that was evidenced by increasing malondialdehyde (MDA) and decreasing ferric reducing antioxidant power (FRAP) and catalase (CAT) activity.
SUPPRESSION OF MALE REPRODUCTIVE FUNCTION BY BROWN HT IN RAT
TLDR
It is concluded that Brown HT suppresses the male reproductive functions probably by producing oxidative stress in testicular tissues and suppressing the hypothalamus-anterior pituitary-testicular axis in rat.
EFFECT OF NATURAL AND SYNTHETIC FOOD COLORANTS ON SPERMATOGENESIS AND THE EXPRESSION OF ITS CONTROLLING GENES
TLDR
Carmoisine induced hazardous effects on fertility at different levels when consumed in concentrations higher than the acceptable daily-authorized level (50 mg/kg b.wt).
Adverse Effects of Some Food Additives in Adult Male Albino Rats
TLDR
It is concluded that tartrazine, monosodium glutamate, sunset yellow, and sodium benzoate adversely affect and alter different biochemical parameters, especially those related to vital organs e.g. liver and kidney and that sunset yellow has the least adverse effects in comparison with the other food additives.
Pemberian resveratrol oral mencegah peningkatan F2-Isoprostan urin tikus Wistar (Rattus norvegicus) jantan yang dipapar tartrazine
TLDR
It is proved that oral administration of resveratrol could prevent urinary F2-isoprostane elevation in tartrazine-induced male Wistar rats (Rattus norvegicus) using the pretest-posttest control group design.
A comprehensive effect of acephate on cauda epididymis and accessory sex organs of male rats
TLDR
A statistically significant increase was noticed in protein content whereas sialic acid content was decreased in the cauda epididymis and accessory sex organs, which support the occurrence of toxicity being caused due to exposure of acephate.
Variability in antioxidant/detoxification enzymes of Labeo rohita exposed to an azo dye, acid black (AB).
  • S. KaurA. Kaur
  • Biology
    Comparative biochemistry and physiology. Toxicology & pharmacology : CBP
  • 2015
...
...

References

SHOWING 1-10 OF 43 REFERENCES
Modulation of N-nitrosodiethylamine (NDEA) induced oxidative stress by vitamin E in rat erythrocytes
TLDR
It is demonstrated that the pre-treatment with vitamin E prior to the administration of NDEA was effective in counteracting and modulating oxidative stress in rat erythrocytes in a time-dependent manner.
A 90­DAY ORAL TOXICITY STUDY OF TARTRAZINE, A SYNTHETIC FOOD DYE, IN WISTAR RATS
The following study is about Tartrazine (E 102) which is known as an azo dye used in food products, drugs and cosmetics. As a part of the safety assessment of Tartrazine, a 13‐week subchronic oral…
Effect of food azo dye tartrazine on learning and memory functions in mice and rats, and the possible mechanisms involved.
TLDR
Tartrazine extract significantly enhanced active behavioral response to the open field, increased the escape latency in Morris water maze test and decreased the retention latency in step-through tests, which indicated that more extensive assessment of food additives in current use is warranted.
Reproductive Toxicology of Tartrazine (FD and C Yellow No. 5) in Swiss Albino Mice
TLDR
It was concluded that excessive tartrazine consumption can have adverse effects on the male reproductive function and suggested conducting surveys among the population to estimate their daily intake.
Oxidative stress and antioxidant defenses after prolonged starvation in Dentex dentex liver.
Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats.
The mechanisms by which Oxidative Stress and Free Radical Damage produces Male infertility
TLDR
The receiver operating characteristic curve analysis revealed a high diagnostic value for PON-1 activity with respect to male-factor sub fertility, and there is a lack of consensus as to the clinical utility of seminal OS testing in an infertility clinic.
Role of reactive oxygen species in male infertility.
Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation) and its individual constituents in reversing haloperidol-induced catalepsy in mice
TLDR
The antioxidant potential of NR-ANX-C and its individual constituents has contributed to the reduction in the oxidative stress and the catalepsy induced by haloperidol administration in Swiss albino mice.
The role of copper, molybdenum, selenium, and zinc in nutrition and health.
...
...