Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection

  title={Oxidative Stress and Vitiligo: The Nrf2-ARE Signaling Connection},
  author={Lei Qiu and Zhiqi Song and Vijayasaradhi Setaluri},
  booktitle={The Journal of investigative dermatology},
Hypersensitivity of epidermal melanocytes to oxidative stress is known to contribute to vitiligo pathogenesis. Molecular mechanisms that connect melanocyte redox homeostasis to the complex disease phenotype are not fully understood. Jian et al. show that vitiligo melanocytes have impaired nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element signaling and decreased activation of the antioxidant enzyme system. In patients with vitiligo, higher serum levels of IL-2… CONTINUE READING

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