Oxidative Stress and Stress-signaling in Chemoprevention of Early Colon Cancer by Diclofenac

Role of oxidative stress and NF-κB signalling was evaluated in the chemopreventive effects of diclofenac, a dual cycloxygenase inhibitor in 1,2-dimethylhydrazine dihydrochloride (DMH)-induced colon carcinogenesis in rat model. After a 6 week long treatment with DMH (early stage), morphological analysis revealed marked occurrence of preneoplastic features… CONTINUE READING