Oxidative Stress and Neurodegenerative Disorders

@article{Li2013OxidativeSA,
  title={Oxidative Stress and Neurodegenerative Disorders},
  author={J. Li and Wuliji O and Wei Li and Zhi-Gang Jiang and Hossein A. Ghanbari},
  journal={International Journal of Molecular Sciences},
  year={2013},
  volume={14},
  pages={24438 - 24475}
}
  • J. Li, W. O, H. Ghanbari
  • Published 22 March 2007
  • Biology
  • International Journal of Molecular Sciences
Living cells continually generate reactive oxygen species (ROS) through the respiratory chain during energetic metabolism. ROS at low or moderate concentration can play important physiological roles. However, an excessive amount of ROS under oxidative stress would be extremely deleterious. The central nervous system (CNS) is particularly vulnerable to oxidative stress due to its high oxygen consumption, weakly antioxidative systems and the terminal-differentiation characteristic of neurons… 
View PDF
319 Citations
Highly Influential Citations
16
Background Citations
119
Methods Citations
1
Results Citations
2

Figures from this paper

319 Citations

Citation Type

Citation Type

Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders
Protective Effect of Osmundacetone against Neurological Cell Death Caused by Oxidative Glutamate Toxicity
TLDR
OAC showed a neuroprotective effect against glutamate toxicity at a concentration of 2 μM, and significantly suppressed the phosphorylation of mitogen-activated protein kinases (MAPKs), including c-Jun NH2-terminal kinase (JNK), extracellular signal-regulated kinase and p38 kinases, which could be a potential agent for supportive treatment of neurodegenerative diseases.
Neuroprotective Effect of Antioxidants in the Brain
TLDR
This review focuses on enzymatic and non-enzymatic antioxidant mechanisms in the brain and examines the relative advantages and methodological concerns when assessing antioxidant compounds for the treatment of neurodegenerative disorders.
Oxidative Stress and the Central Nervous System
  • S. Salim
  • Psychology, Biology
    The Journal of Pharmacology and Experimental Therapeutics
  • 2017
TLDR
This review is a discussion of the relevance of cerebral oxidative stress to impairment of emotional and mental well-being in neuropsychiatric disorders, including anxiety disorders and depression.
When It Comes to an End: Oxidative Stress Crosstalk with Protein Aggregation and Neuroinflammation Induce Neurodegeneration
TLDR
The interplay among oxidative stress, proteinopathy, and neuroinflammation at the early stages of neurodegenerative diseases is discussed and the use of the Nrf2-ARE pathway as a potential therapeutic strategy based on these molecular mechanisms to develop transformative medicines is discussed.
Nitroxide antioxidant as a potential strategy to attenuate the oxidative/nitrosative stress induced by hydrogen peroxide plus nitric oxide in cultured neurons.
Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction.
Oxidative Stress and Huntington’s Disease: The Good, The Bad, and The Ugly
TLDR
Oxidative stress has long been held to be one of the key players in disease progression for Huntington’s disease (HD), and this review will critically review this evidence, drawing some intermediate conclusions, and provide a framework for thinking about the role of oxidative stress in the pathophysiology of HD.
Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases
TLDR
The diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases are discussed.
Essential Dietary Bioactive Lipids in Neuroinflammatory Diseases.
TLDR
It is highlighted that experimental and clinical findings, although promising, are still inadequate to draw definitive conclusions about the impact of lipid intake on brain health, especially when redox balance and inflammatory responses have been already compromised.
...
...

References

SHOWING 1-10 OF 266 REFERENCES
Mechanism of Oxidative Stress in Neurodegeneration
TLDR
The hypothesis that oxidative stress is a crucial player in common neurodegenerative disease is critically assessed and the issues surrounding the failure to translate this hypothesis into an effective clinical treatment are examined.
Oxidative Nerve Cell Death in Alzheimers Disease and Stroke: Antioxidants as Neuroprotective Compounds
TLDR
The neuroprotective potential of antioxidant phenolic structures including αtocopherol (vitamin E) and 17βestradiol (estrogen) in vitro is summarized and an outlook is given on the neuroprot protective potential of aromatic amines and imines, which may comprise novel lead structures for antioxidant drug design.
Reactive oxygen species in the regulation of synaptic plasticity and memory.
TLDR
The review shows that the inability to restrain either age- or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function.
PAN-811 inhibits oxidative stress-induced cell death of human Alzheimer's disease-derived and age-matched olfactory neuroepithelial cells via suppression of intracellular reactive oxygen species.
TLDR
PAN-811 is shown to be effective in preventing or reducing ROS accumulation and the resulting oxidative damages in both AD-derived and age-matched olfactory neuroepithelial cells.
Regulation and measurement of oxidative stress in apoptosis.
Free radicals and antioxidants in normal physiological functions and human disease.
Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells
The importance of glutathione in human disease.
Glutathione elevation by γ‐glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain
TLDR
This study test the hypothesis that, by elevating brain levels of GSH, the brain would be protected against oxidative stress in ADR‐injected mice, and results are discussed with regard to potential pharmacological prevention of brain cognitive dysfunction in patients receiving ADR chemotherapy.
Melatonin abrogates cadmium induced oxidative stress related neurotoxicity in rats.
TLDR
Melatonin markedly reduced the Cd induced pathological changes and preserved the normal histological architecture of the brain tissue in rats, suggesting that melatonin may be beneficial in combating the cadmium induced oxidative neurotoxicity in the brain of rats.
...
...