Oxidative Stress and Neurodegenerative Disorders

  title={Oxidative Stress and Neurodegenerative Disorders},
  author={J. Li and Wuliji O and Wei Li and Zhi-Gang Jiang and Hossein A. Ghanbari},
  journal={International Journal of Molecular Sciences},
  pages={24438 - 24475}
  • J. Li, W. O, H. Ghanbari
  • Published 22 March 2007
  • Biology
  • International Journal of Molecular Sciences
Living cells continually generate reactive oxygen species (ROS) through the respiratory chain during energetic metabolism. ROS at low or moderate concentration can play important physiological roles. However, an excessive amount of ROS under oxidative stress would be extremely deleterious. The central nervous system (CNS) is particularly vulnerable to oxidative stress due to its high oxygen consumption, weakly antioxidative systems and the terminal-differentiation characteristic of neurons… 

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