Oxidative Stress and DNA Lesions: The Role of 8-Oxoguanine Lesions in Trypanosoma cruzi Cell Viability

@inproceedings{Aguiar2013OxidativeSA,
  title={Oxidative Stress and DNA Lesions: The Role of 8-Oxoguanine Lesions in Trypanosoma cruzi Cell Viability},
  author={Pedro Henrique Nascimento Aguiar and Carolina de Gusm{\~a}o Furtado and Bruno Marçal Repol{\^e}s and Grazielle Alves Ribeiro and Isabela Cec{\'i}lia Mendes and Eduardo de Figueiredo Peloso and Fernanda R Gadelha and Alexandro Sousa Macedo and Gl{\'o}ria Regina Franco and S{\'e}rgio D. Junho Pena and Santuza Maria Ribeiro Teixeira and Leda Quercia Vieira and Alessandra Aparecida Guarneri and Luciana O Andrade and Carlos Renato Machado},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
The main consequence of oxidative stress is the formation of DNA lesions, which can result in genomic instability and lead to cell death. Guanine is the base that is most susceptible to oxidation, due to its low redox potential, and 8-oxoguanine (8-oxoG) is the most common lesion. These characteristics make 8-oxoG a good cellular biomarker to indicate the extent of oxidative stress. If not repaired, 8-oxoG can pair with adenine and cause a G:C to T:A transversion. When 8-oxoG is inserted during… CONTINUE READING

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