Oxidative Stress Status During Exposure to Propofol, Sevoflurane and Desflurane

@article{Allaouchiche2001OxidativeSS,
  title={Oxidative Stress Status During Exposure to Propofol, Sevoflurane and Desflurane},
  author={Bernard Allaouchiche and Richard Debon and Joelle Goudable and Dominique Chassard and Fr{\'e}d{\'e}ric Duflo},
  journal={Anesthesia \& Analgesia},
  year={2001},
  volume={93},
  pages={981–985}
}
We evaluated the circulating and lung oxidative status during general anesthesia established with propofol, sevoflurane, or desflurane in mechanically ventilated swines. Blood samples and bronchoalveolar lavage fluid (BAL) specimens were respectively performed via an internal jugular vein catheter and a nonbronchoscopic BAL for baseline oxidative activity measurements: malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX). A 4-h general anesthesia was then… 

Study of the systemic and pulmonary oxidative stress status during exposure to propofol and sevoflurane anaesthesia during thoracic surgery.

Sevoflurane appears to cause a greater intrapulmonary proinflammatory response than propofol during thoracic surgery, whereas prop ofol is more likely to have antioxidant properties.

Effect of Propofol, Sevoflurane and Desflurane on Systemic Redox Balance

Propofol showed antioxidant properties, while Sevoflurane and Desflurane seemed to shift the redox balance towards oxidation, yet without inducing overt oxidative damage.

Oxidative and Antioxidative Effects of Desflurane and Sevoflurane on Rat Tissue in Vivo

The results suggest that anaesthesiologist should not only be aware of the oxidative or antioxidative potential of anaesthetics they use, but should also base their choices on organs which are the most affected by their oxidative action.

The effect of sevoflurane and desflurane on markers of oxidative status in erythrocyte

The results showed that sevoflurane has more impacts on the antioxidant status of erythrocytes than desflurane.

The effects of sevoflurane and desflurane on lipid peroxidation during laparoscopic cholecystectomy

Desflurane may cause more systemic and regional lipid peroxidation than sevoflurane during laparoscopic cholecystectomy in healthy human beings.

Effects of sevoflurane and desflurane on oxidative stress during general anesthesia for elective cesarean section

Oxidative stress indices might be modified with preferred anesthetic agent and sevoflurane showed more favorable effects than desflurane in view of oxidative stress.

New volatile anesthetic, desflurane, reduces vitamin E level in blood of operative patients via oxidative stress

It is observed that desflurane produced oxidative stress by decreasing α‐tocopherol levels, and use of vitamin E may be possible to reduce the oxidative effect of desFlurane.

Oxidant and antioxidant activities of different anesthetic techniques. Propofol versus desflurane.

This study may be defined to support the fact that free oxygen radicals were released more by desflurane than propofol, and a systemic oxidative stress increment with desFLurane by terms of MDA; a lipid peroxidation product and endogenous antioxidant activity suppression at only peroperative period.

Balanced anesthesia with sevoflurane does not alter redox status in patients undergoing surgical procedures.

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