Oxidative Stress Status During Exposure to Propofol, Sevoflurane and Desflurane

  title={Oxidative Stress Status During Exposure to Propofol, Sevoflurane and Desflurane},
  author={Bernard Allaouchiche and Richard Debon and Joelle Goudable and Dominique Chassard and Fr{\'e}d{\'e}ric Duflo},
  journal={Anesthesia \& Analgesia},
We evaluated the circulating and lung oxidative status during general anesthesia established with propofol, sevoflurane, or desflurane in mechanically ventilated swines. Blood samples and bronchoalveolar lavage fluid (BAL) specimens were respectively performed via an internal jugular vein catheter and a nonbronchoscopic BAL for baseline oxidative activity measurements: malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPX). A 4-h general anesthesia was then… 

Study of the systemic and pulmonary oxidative stress status during exposure to propofol and sevoflurane anaesthesia during thoracic surgery.

Sevoflurane appears to cause a greater intrapulmonary proinflammatory response than propofol during thoracic surgery, whereas prop ofol is more likely to have antioxidant properties.

Effect of Propofol, Sevoflurane and Desflurane on Systemic Redox Balance

Propofol showed antioxidant properties, while Sevoflurane and Desflurane seemed to shift the redox balance towards oxidation, yet without inducing overt oxidative damage.

Oxidative and Antioxidative Effects of Desflurane and Sevoflurane on Rat Tissue in Vivo

The results suggest that anaesthesiologist should not only be aware of the oxidative or antioxidative potential of anaesthetics they use, but should also base their choices on organs which are the most affected by their oxidative action.

The effect of sevoflurane and desflurane on markers of oxidative status in erythrocyte

The results showed that sevoflurane has more impacts on the antioxidant status of erythrocytes than desflurane.

The effects of sevoflurane and desflurane on lipid peroxidation during laparoscopic cholecystectomy

Desflurane may cause more systemic and regional lipid peroxidation than sevoflurane during laparoscopic cholecystectomy in healthy human beings.

Effects of sevoflurane and desflurane on oxidative stress during general anesthesia for elective cesarean section

Oxidative stress indices might be modified with preferred anesthetic agent and sevoflurane showed more favorable effects than desflurane in view of oxidative stress.

New volatile anesthetic, desflurane, reduces vitamin E level in blood of operative patients via oxidative stress

It is observed that desflurane produced oxidative stress by decreasing α‐tocopherol levels, and use of vitamin E may be possible to reduce the oxidative effect of desFlurane.

Oxidant and antioxidant activities of different anesthetic techniques. Propofol versus desflurane.

This study may be defined to support the fact that free oxygen radicals were released more by desflurane than propofol, and a systemic oxidative stress increment with desFLurane by terms of MDA; a lipid peroxidation product and endogenous antioxidant activity suppression at only peroperative period.

Balanced anesthesia with sevoflurane does not alter redox status in patients undergoing surgical procedures.

  • J. OroszL. Braz M. Braz
  • Biology, Medicine
    Mutation research. Genetic toxicology and environmental mutagenesis
  • 2014



The effect of propofol on oxidative stress in platelets from surgical patients.

The findings show that propofol has an antioxidant effect in humans, and may be beneficial in patients who have diseases in which free radicals play an important role, and could be applied in the protection of tissues from ischemic damage.

The In Vitro Effects of Propofol on Tissular Oxidative Stress in the Rat

It is concluded that propofol not only inhibits lipid peroxidation, but also enhances the cellular antioxidant defense system, and is thus able to prepare tissues against oxidative attack by boosting stores of reduced glutathione.

Volatile anesthetics augment expression of proinflammatory cytokines in rat alveolar macrophages during mechanical ventilation.

Gene expression of proinflammatory cytokines increase after inhalation of volatile anesthetics under mechanical ventilation, and significant increases in lavage concentrations of MIP-2 and TNF-alpha were observed.

Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction.

These data indicate decreased antioxidant status in the face of enhanced free radical activity, and suggest potential therapeutic strategies involving antioxidant repletion.

Expression of genes for proinflammatory cytokines in alveolar macrophages during propofol and isoflurane anesthesia.

The data indicate that the pulmonary inflammatory response accompanying anesthesia and surgery is accompanied by the expression of proinflammatory cytokines, and that this expression was in some cases greater during isoflurane than propofol anesthesia.

Loss of Alveolar Macrophages During Anesthesia and Operation in Humans

There was a strong correlation between loss of macrophages and the duration of surgery and anesthesia, and aggregation increased and viability decreased as a function of procedure length.

Expired breath hydrogen peroxide is a marker of acute airway inflammation in pediatric patients with asthma.

Elevation of H2O2 in the expired breath condensate is a simple, noninvasive method that can be used as a biochemical marker of airway inflammation.

Malondialdehyde kit evaluated for determining plasma and lipoprotein fractions that react with thiobarbituric acid.

The results reported here indicate that the malondialdehyde (MDA) kit manufactured by Sobioda complies with criteria of good analytical practices.

The antioxidant potential of propofol (2,6-diisopropylphenol).

It is concluded that the free radical scavenging properties of 2,6-diisopropylphenol resemble those of the endogenous antioxidant alpha-tocopherol (vitamin E).