Oxidative Stress Response Tips the Balance in Aspergillus terreus Amphotericin B Resistance.

Abstract

In this study, we characterize the impact of antioxidative enzymes in amphotericin B (AmB)-resistant (ATR) and rare AmB-susceptible (ATS) clinical Aspergillus terreus isolates. We elucidate expression profiles of superoxide dismutase (SOD)- and catalase (CAT)-encoding genes, enzymatic activities of SODs, and superoxide anion production and signaling… (More)
DOI: 10.1128/AAC.00670-17

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