Oxidative Stress Regulates Adipocyte Apolipoprotein E and Suppresses Its Expression in Obesity

@article{Espiritu2008OxidativeSR,
  title={Oxidative Stress Regulates Adipocyte Apolipoprotein E and Suppresses Its Expression in Obesity},
  author={Doris Joy D Espiritu and Theodore Mazzone},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={2992 - 2998}
}
OBJECTIVE Endogenous expression of apolipoprotein E (apoE) has a significant impact on adipocyte lipid metabolism and is markedly suppressed in obesity. Adipose tissue oxidant stress is emerging as an important mediator of adipocyte dysfunction. These studies were undertaken to evaluate the role of oxidant stress for regulation of adipocyte apoE. RESEARCH DESIGN AND METHODS ApoE gene and protein expression in 3T3-L1 adipocytes or mature adipocytes and adipose tissue from C57/BL6 mice was… CONTINUE READING

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