Oxidative Stress Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX 1 / 2 Is Reversed by NADPH Oxidase Inhibition

@inproceedings{Wind2010OxidativeSO,
  title={Oxidative Stress Oxidative Stress and Endothelial Dysfunction in Aortas of Aged Spontaneously Hypertensive Rats by NOX 1 / 2 Is Reversed by NADPH Oxidase Inhibition},
  author={Sven Wind and Knut Beuerlein and Melanie E. Armitage and Ashraf Taye and Arun H. S. Kumar and Daniel Janowitz and Christina Neff and Ajay M. Shah and Kirstin Wingler and Harald H H W Schmidt},
  year={2010}
}
Arterial hypertension is associated with increased levels of reactive oxygen species, which may scavenge endothelium-derived NO and thereby diminish its vasorelaxant effects. However, the quantitatively relevant source of reactive oxygen species is unclear. Thus, this potential pathomechanism is not yet pharmacologically targetable. Several enzymatic sources of reactive oxygen species have been suggested: uncoupled endothelial NO synthase, xanthine oxidase, and NADPH oxidases. Here we show that… CONTINUE READING

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