Oxidative Stress Induced by Ureteral Obstruction and Tadalafil

@inproceedings{Cirrik2017OxidativeSI,
  title={Oxidative Stress Induced by Ureteral Obstruction and Tadalafil},
  author={Selma Cirrik and Sema Nur Ayyıldız and Erdal Benli and Ali Ayyildiz and Tevfik Noyan and Rustu Cankon Germiyanoglu and Abdullah Çırakoğlu},
  year={2017}
}
Objective: It has been reported that tadalafil, a specific phosphodiesterase-5 (PDE5) inhibitor, has an antioxidant effect besides its well-known vasoactive properties. This study aimed to determine the possible protective effects of tadalafil in managing renal oxidative stress induced by unilateral ureteral obstruction (UUO). Methods: Male Sprague-Dawley rats aged 2.5-3 months were randomly divided into 5 groups (n=8) as sham (P), partial obstruction (P), P+tadalafil (PT), complete obstruction… CONTINUE READING

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