Oxidative Stress Dependent Autocrine Loop in Response to − Receptor like Growth Factor into an Epidermal Growth Factor − Factor Trafficking of Nuclear Heparin-Binding Epidermal Growth

@inproceedings{Kim2005OxidativeSD,
  title={Oxidative Stress Dependent Autocrine Loop in Response to − Receptor like Growth Factor into an Epidermal Growth Factor − Factor Trafficking of Nuclear Heparin-Binding Epidermal Growth},
  author={Jayoung Kim and Rosalyn M Adam and Michael R. Freeman},
  year={2005}
}
Heparin-binding epidermal growth factor (EGF)–like growth factor (HB-EGF) accumulates in the nucleus in aggressive transitional cell carcinoma (TCC) cells and this histologic feature is a marker of poor prognosis in human bladder cancer tissues. Here we report that HB-EGF can be exported from the nucleus during stimulated processing and secretion of the… CONTINUE READING