Oxidative Demethylation and Carcinogenicity of 4-N-Dimethylaminoazobenzene Derivatives

@article{Ishidate1961OxidativeDA,
  title={Oxidative Demethylation and Carcinogenicity of 4-N-Dimethylaminoazobenzene Derivatives},
  author={M Ishidate and Akira Hanaki},
  journal={Nature},
  year={1961},
  volume={191},
  pages={1198-1199}
}
RECENT work on the hepatocarcinogenic amino-azo compounds has shown that the presence of at least one N-methyl group and the formation of a firmly bound compound between metabolites of the azo compound and rat-liver proteins are probably necessary for the strong activity1. The biochemical behaviour of N-methyl groups with respect to the protein-bound polar… CONTINUE READING