Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase.

@article{Murata2004OxidativeDD,
  title={Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase.},
  author={M. Murata and S. Ohnishi and Kazuharu Seike and K. Fukuhara and N. Miyata and S. Kawanishi},
  journal={Chemical research in toxicology},
  year={2004},
  volume={17 12},
  pages={
          1750-6
        }
}
Nitropyrenes are widespread in the environment due to mainly diesel engine emissions. Dinitropyrenes (DNPs), especially 1,8-dinitropyrene (1,8-DNP) and 1,6-dinitropyrene (1,6-DNP), are much more potent mutagens than other nitropyrenes. The carcinogenicity of 1,8-DNP and 1,6-DNP is stronger than 1,3-dinitropyrene (1,3-DNP). It is considered that adduct formation after metabolic activation plays an important role in the expression of carcinogenicity of nitropyrenes. However, Djuric et al. [(1993… Expand
Mechanisms of oxidative DNA damage induced by carcinogenic arylamines.
Nitroaromatic compounds: Environmental toxicity, carcinogenicity, mutagenicity, therapy and mechanism
Contributions of human enzymes in carcinogen metabolism.
...
1
2
...