Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism.

  title={Oxidative DNA damage in gastric cancer: CagA status and OGG1 gene polymorphism.},
  author={Fabio Farinati and Romilda Cardin and Marina Bortolami and Donato Nitti and Daniela Basso and Marina de Bernard and M. A. Cassaro and A. Martinez D. Sergio and M Rugge},
  journal={International journal of cancer},
  volume={123 1},
Oxidative DNA damage is thought to play an important part in the pathogenesis of H. pylori-induced mucosal damage. 8-OHdG is a sensitive marker of DNA oxidation and is repaired by a polymorphic glycosylase (OGG1) more effectively than by OGG1-Cys(326). The aims of this study were to ascertain the respective roles of H. pylori, cagA status and OGG1 polymorphism in determining 8-OHdG levels in benign and premalignant stomach diseases and in gastric cancer (GC). The study involved 50 GC patients… CONTINUE READING


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