Oxidative DNA damage in diabetes mellitus: its association with diabetic complications

@article{Hinokio1999OxidativeDD,
  title={Oxidative DNA damage in diabetes mellitus: its association with diabetic complications},
  author={Yoshinori Hinokio and Shigeru Suzuki and Masashi Hirai and M. Chiba and A. Hirai and Takayoshi Toyota},
  journal={Diabetologia},
  year={1999},
  volume={42},
  pages={995-998}
}
Aims/hypothesis. Augmented oxidative stress induced by hyperglycaemia possibly contributes to the pathogenesis of diabetic complications. Oxidative stress is known to increase the conversion of deoxyguanosine to 8-oxo, 2 ′-deoxyguanosine in DNA. To investigate the possible contribution of oxidative DNA damage to the pathogenesis of diabetic complications, we measured the content of 8-oxo, 2 ′-deoxyguanosine in the urine and the blood mononuclear cells of Type II (non-insulin-dependent) diabetic… CONTINUE READING