Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma

@inproceedings{Romilda2011OxidativeDD,
  title={Oxidative DNA damage correlates with cell immortalization and mir-92 expression in hepatocellular carcinoma},
  author={Cardin Romilda and Piciocchi Marika and Sinigaglia Alessandro and Lavezzo Enrico and Bortolami Marina and Kotsafti Andromachi and Cillo Umberto and Zanus Giacomo and Mescoli Claudia and Rugge Massimo and Farinati Fabio},
  booktitle={BMC Cancer},
  year={2011}
}
MicroRNAs expression has been extensively studied in hepatocellular carcinoma but little is known regarding the relationship, if any, with inflammation, production of reactive oxygen species (ROS), host’s repair mechanisms and cell immortalization. This study aimed at assessing the extent of oxidative DNA damage (8-hydroxydeoxyguanosine - 8-OHdG) in different phases of the carcinogenetic process, in relation to DNA repair gene polymorphism, telomeric dysfunction and to the expression of several… CONTINUE READING

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