Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae.

@article{Doudican2005OxidativeDD,
  title={Oxidative DNA damage causes mitochondrial genomic instability in Saccharomyces cerevisiae.},
  author={Nicole A. Doudican and Binwei Song and Gerald S Shadel and Paul W. Doetsch},
  journal={Molecular and cellular biology},
  year={2005},
  volume={25 12},
  pages={5196-204}
}
Mitochondria contain their own genome, the integrity of which is required for normal cellular energy metabolism. Reactive oxygen species (ROS) produced by normal mitochondrial respiration can damage cellular macromolecules, including mitochondrial DNA (mtDNA), and have been implicated in degenerative diseases, cancer, and aging. We developed strategies to elevate mitochondrial oxidative stress by exposure to antimycin and H(2)O(2) or utilizing mutants lacking mitochondrial superoxide dismutase… CONTINUE READING