Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II).

  title={Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II).},
  author={S. Singh and S. F. Asad and A. Ahmad and Nizam Uddin Khan and S. M. Hadi},
  journal={Cancer letters},
  volume={169 2},

A synergistic effect of Cu(2+) and norbixin on DNA damage.

  • Di OuyangRong ZhangLong YiZ. Xi
  • Chemistry, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2008

Prooxidant action of chebulinic acid and tellimagrandin I: causing copper-dependent DNA strand breaks.

A Comprehensive Review of the Carcinogenic and Anticarcinogenic Potential of Capsaicin

Recent studies utilizing high-purity capsaicin and standardized protocols provide evidence that the genotoxic and carcinogenic potential of Capsaicin is quite low and that the purity of capsicin is important.

Recent advances in the study on capsaicinoids and capsinoids.

Herbal bioactivation: The good, the bad and the ugly

A synergistic effect of GABA tea and copper(II) on DNA breakage in human peripheral lymphocytes.

Perspectives on medicinal properties of plumbagin and its analogs

It has been suggested that designing “hybrid drug molecules” of plumbagin by combining it with other appropriate anticancer agents may lead to the generation of novel and potent anticancer drugs with pleiotropic action against human cancers.



Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen free radicals.

From data, a mechanism for the DNA strand scission reaction of quercetin and related flavonoids is proposed andCu(I) was shown to be an essential intermediate by using the Cu(I)-sequestering reagents, neoc uproine and bathocuproine.

1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions.

Findings demonstrate the promotion of hydroxyl-radical-mediated DNA damage by endogenous Cu2+ and demonstrate that the internucleosomal DNA 'laddering' that is often used as an indicator of apoptosis may also result from DNA fragmentation by non-enzymic processes.

Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis.

The topical application of capsaicin did not induce the epidermal ornithine decarboxylase activity, suggesting that it lacks tumor-promotional activity, and the compound ameliorated the mouse skin carcinogenesis when given simultaneously with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.

Structural features of tannic acid important for DNA degradation in the presence of Cu(II).

The results indicate that the DNA cleavage activity of tannic acid is due to its digalloyl moeity and that free hydroxyl groups are essential for cleavage.

Activities of flavonoids for the cleavage of DNA in the presence of Cu(II): correlation with generation of active oxygen species.

The activities of several flavonoids and the related nonflavonoid compound epicatechin were compared with respect to Cu(II)-induced strand scission of DNA by using two different assays and analysis of the data led to a discussion of alternative Cu( II)-sequestering mechanisms.

Uric acid inhibits l-DOPA-CU(II) mediated DNA cleavage