Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II).

@article{Singh2001OxidativeDD,
  title={Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II).},
  author={S. Singh and S. F. Asad and A. Ahmad and Nizam Uddin Khan and S. M. Hadi},
  journal={Cancer letters},
  year={2001},
  volume={169 2},
  pages={
          139-46
        }
}
View on PubMed
doi.org
57 Citations
Highly Influential Citations
2
Background Citations
21
Results Citations
1

57 Citations

A synergistic effect of Cu(2+) and norbixin on DNA damage.

  • Di OuyangRong ZhangLong YiZ. Xi
  • Chemistry, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2008

Prooxidant action of chebulinic acid and tellimagrandin I: causing copper-dependent DNA strand breaks.

Micronuclei and sister chromatid exchanges induced by capsaicin in human lymphocytes.

Mechanism of DNA damage induced by arecaidine: The role of Cu(II) and alkaline conditions

Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid DNA.

Recent advances in the study on capsaicinoids and capsinoids.

Herbal bioactivation: The good, the bad and the ugly

A synergistic effect of GABA tea and copper(II) on DNA breakage in human peripheral lymphocytes.

Antimicrobial Activity of Selected Polyphenols and Capsaicinoids Identified in Pepper (Capsicum annuum L.) and Their Possible Mode of Interaction

Antimicrobial activity of pepper polyphenols and capsaicinoids against 13 pathogen bacteria and three beneficial strains was studied using the disk diffusion and microdilution methods and phenolic compounds had the most important activity with the highest inhibition zones obtained.

Perspectives on medicinal properties of plumbagin and its analogs

It has been suggested that designing “hybrid drug molecules” of plumbagin by combining it with other appropriate anticancer agents may lead to the generation of novel and potent anticancer drugs with pleiotropic action against human cancers.
...

References

SHOWING 1-10 OF 31 REFERENCES

Capsaicin, a double-edged sword: toxicity, metabolism, and chemopreventive potential.

DNA breakage by resveratrol and Cu(II): reaction mechanism and bacteriophage inactivation.

Strand scission in DNA induced by quercetin and Cu(II): role of Cu(I) and oxygen free radicals.

From data, a mechanism for the DNA strand scission reaction of quercetin and related flavonoids is proposed andCu(I) was shown to be an essential intermediate by using the Cu(I)-sequestering reagents, neoc uproine and bathocuproine.

1,10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat-liver nuclei by promoting the redox activity of endogenous copper ions.

Findings demonstrate the promotion of hydroxyl-radical-mediated DNA damage by endogenous Cu2+ and demonstrate that the internucleosomal DNA 'laddering' that is often used as an indicator of apoptosis may also result from DNA fragmentation by non-enzymic processes.

Lack of tumor promoting activity of capsaicin, a principal pungent ingredient of red pepper, in mouse skin carcinogenesis.

The topical application of capsaicin did not induce the epidermal ornithine decarboxylase activity, suggesting that it lacks tumor-promotional activity, and the compound ameliorated the mouse skin carcinogenesis when given simultaneously with the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate.

Inhibition by capsaicin against cyclophosphamide-induced clastogenicity and DNA damage in mice.

DNA breakage by tannic acid and Cu(II): sequence specificity of the reaction and involvement of active oxygen species.

Structural features of tannic acid important for DNA degradation in the presence of Cu(II).

The results indicate that the DNA cleavage activity of tannic acid is due to its digalloyl moeity and that free hydroxyl groups are essential for cleavage.

Uric acid inhibits l-DOPA-CU(II) mediated DNA cleavage

Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin.