Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD).

@article{Starcevic2003OxidativeDD,
  title={Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD).},
  author={S. L. Starcevic and N. Diotte and K. Zukowski and M. Cameron and R. Novak},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2003},
  volume={75 1},
  pages={
          74-81
        }
}
  • S. L. Starcevic, N. Diotte, +2 authors R. Novak
  • Published 2003
  • Medicine, Biology
  • Toxicological sciences : an official journal of the Society of Toxicology
  • Oxidative damage to DNA is thought to play a significant role in mutagenesis, aging, and cancer. Sensitivity to oxidative DNA damage and DNA repair efficiency were examined using a series of human breast epithelial cell lines-MCF-10A, MCF-10AT, and MCF-10ATG3B-with progressively elevated Ras protein. Breast epithelial cells were treated with H2O2, in the absence and presence of the DNA-repair inhibitors hydroxyurea (HU) and cytosine arabinoside (Ara-C). DNA strand breaks were assessed by the… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 32 REFERENCES
    Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease.
    • 28
    • PDF
    Genotoxicity of human milk extracts and detection of DNA damage in exfoliated cells recovered from breast milk.
    • 25
    • Highly Influential
    Deregulated manganese superoxide dismutase expression and resistance to oxidative injury in p53-deficient cells.
    • 138
    • PDF
    Increased growth capacity of cervical‐carcinoma cells over‐expressing manganous superoxide dismutase
    • 38