Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD).

@article{Starcevic2003OxidativeDD,
  title={Oxidative DNA damage and repair in a cell lineage model of human proliferative breast disease (PBD).},
  author={Susan L Starcevic and Nicole M Diotte and Kim L Zukowski and Mark J Cameron and Raymond F. Novak},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2003},
  volume={75 1},
  pages={74-81}
}
Oxidative damage to DNA is thought to play a significant role in mutagenesis, aging, and cancer. Sensitivity to oxidative DNA damage and DNA repair efficiency were examined using a series of human breast epithelial cell lines-MCF-10A, MCF-10AT, and MCF-10ATG3B-with progressively elevated Ras protein. Breast epithelial cells were treated with H2O2, in the absence and presence of the DNA-repair inhibitors hydroxyurea (HU) and cytosine arabinoside (Ara-C). DNA strand breaks were assessed by the… CONTINUE READING

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