Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline.

@article{Soh2003OxidativeDD,
  title={Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline.},
  author={Yunjo Soh and Mi-Hyun Shin and Jeong-Sang Lee and Jung-Hee Jang and Ok-Hee Kim and Hoil Kang and Young-Joon Surh},
  journal={Mutation research},
  year={2003},
  volume={544 2-3},
  pages={
          129-42
        }
}
A series of naturally occurring isoquinoline alkaloids, besides their distribution in the environment and presence in certain food stuffs, have been detected in human tissues including particular regions of brain. An example is salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) that not only induces neuronal cell death, but also causes DNA damage and genotoxicity. Tetrahydropapaveroline [THP; 6,7-dihydroxy-1-(3',4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline], a dopamine… Expand
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