Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation.

@article{Zwingmann1998OxidativeDD,
  title={Oxidative DNA damage and cytogenetic effects in flight engineers exposed to cosmic radiation.},
  author={I H Zwingmann and Irene J. Welle and Marcel H. M. van Herwijnen and J. J. Engelen and P A E L Schilderman and Tjabe Smid and Jos Kleinjans},
  journal={Environmental and molecular mutagenesis},
  year={1998},
  volume={32 2},
  pages={121-9}
}
This study set out to analyze biomarkers for genotoxic events, e.g., oxidative DNA damage, chromosomal damage and hprt mutations, among flight personnel, who are known to be occupationally exposed to ionizing radiation of cosmic origin. Twenty-three flight engineers were recruited while ground personnel served as a matched control group. Cumulative radiation doses during flight were calculated on the basis of subjects' flight records assuming an exposure rate of 6 microSv per hour of flight… CONTINUE READING

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