Oxidative DNA damage and apoptosis induced by benzene metabolites.

  title={Oxidative DNA damage and apoptosis induced by benzene metabolites.},
  author={Yusuke Hiraku and Shosuke Kawanishi},
  journal={Cancer research},
  volume={56 22},
Benzene is a widely recognized human carcinogen. The mechanism of DNA damage induced by major benzene metabolites 1,4-benzoquinone (1,4-BQ) and hydroquinone (1,4-HQ) was investigated in relation to apoptosis and carcinogenesis. Pulsed-field gel electrophoresis showed that cellular DNA strand breakage was induced by benzene metabolites. Internucleosomal DNA fragmentation and morphological changes of apoptotic cells were observed at higher concentrations of benzene metabolites. Flow cytometry… CONTINUE READING
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