Oxidative DNA damage: mechanisms, mutation, and disease

@article{Cooke2003OxidativeDD,
  title={Oxidative DNA damage: mechanisms, mutation, and disease},
  author={Marcus S. Cooke and Mark David Evans and Miral Dizdaroglu and Joseph Lunec},
  journal={The FASEB Journal},
  year={2003},
  volume={17},
  pages={1195 - 1214}
}
Oxidative DNA damage is an inevitable consequence of cellular metabolism, with a propensity for increased levels following toxic insult. Although more than 20 base lesions have been identified, only a fraction of these have received appreciable study, most notably 8‐oxo‐2′deoxyguanosine. This lesion has been the focus of intense research interest and been ascribed much importance, largely to the detriment of other lesions. The present work reviews the basis for the biological significance of… 

Factors contributing to the outcome of oxidative damage to nucleic acids

  • M. EvansM. Cooke
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2004
TLDR
DNA repair appears pivotal to the maintenance of genome integrity, and genetic alterations in repair capacity, due to single nucleotide polymorphisms or mutation, may account for inter‐individual differences in cancer susceptibility.

Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage.

TLDR
The continuing development and improvement of LC-MS/MS coupled with the stable isotope-dilution method for DNA adduct quantification will further promote research about the clinical implications and diagnostic applications of oxidatively induced DNAAdducts.

Sources of Extracellular, Oxidatively-Modified DNA Lesions: Implications for Their Measurement in Urine

TLDR
Further studies are required to define the relative contributions of metabolism, disease and diet to oxidised nucleic acids and their metabolites in urine in order to develop urinalyis as a better tool for understanding human disease.

Base excision repair of oxidative DNA damage and association with cancer and aging.

TLDR
The association of BER of oxidative DNA damage with aging, cancer and other diseases is reviewed and base excision repair in the nucleus is reviewed.

Role of Oxidative RNA Damage in Chronic-Degenerative Diseases

  • C. Fimognari
  • Biology
    Oxidative medicine and cellular longevity
  • 2015
TLDR
Recent evidence suggesting that RNA may be the target for toxic agents and indicating RNA degradation as a powerful tool to treat any pathology in which there is an aberrant expression of mRNA and/or its gene products is reviewed.

Damage by Peroxisome Proliferators of the Molecular Source of Radicals Responsible for DNA Chemical-induced Chronic Oxidative Stress : Identification Detection of in Vivo Sensitive Biomarker for Expression of Base Excision DNA Repair Genes Is a

TLDR
It is concluded that expression of base excision DNA repair genes is a sensitive in vivo biomarker for chemically induced oxidative stress to DNA that can be successfully used for the identification of the molecular source of radicals responsible for DNA damage in vivo.

Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine

TLDR
The formation of the European Standards Committee on Urinary (DNA) Lesion Analysis is reported, whose primary goal is to achieve consensus between methods and establish reference ranges in health and disease.

Expression of Base Excision DNA Repair Genes Is a Sensitive Biomarker for in Vivo Detection of Chemical-induced Chronic Oxidative Stress

TLDR
It is concluded that expression of base excision DNA repair genes is a sensitive in vivo biomarker for chemically induced oxidative stress to DNA that can be successfully used for the identification of the molecular source of radicals responsible for DNA damage in vivo.
...

References

SHOWING 1-10 OF 201 REFERENCES

Urinary analysis of oxidative DNA damage: Lessons from lesions

TLDR
Significant work still needs to be performed to examine these three parameters and hence further elucidate the kinetics of lesion formation and clearance in vivo and upon establishment of these details, urinary oxidative DNA damage measurements may become more than a reflection of generalised oxidative stress.

Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.

TLDR
Dietary AA protects human sperm from endogenous oxidative DNA damage that could affect sperm quality and increase risk of genetic defects, particularly in populations with low AA such as smokers.

Oxidative DNA Damage and Repair in Experimental Atherosclerosis Are Reversed by Dietary Lipid Lowering

Increased oxidative stress is a major characteristic of hypercholesterolemia-induced atherosclerosis. The oxidative environment is mainly created by the production of reactive oxygen species, which

No Evidence for Increased Oxidative Damage to Lipids, Proteins, or DNA in Huntington's Disease

TLDR
The data suggest that oxidative stress is not a major component of the degenerative processes occurring in Huntington's disease, or at least not to the extent that occurs in other neurodegenerative disorders.

Elevated Levels of Oxidative DNA Damage and DNA Repair Enzymes in Human Atherosclerotic Plaques

TLDR
Evidence is provided that oxidative DNA damage and repair increase significantly in human atherosclerotic plaques and this is accompanied by the upregulation of DNA repair mechanisms.

Oxidative DNA Damage in the Parkinsonian Brain: An Apparent Selective Increase in 8‐Hydroxyguanine Levels in Substantia Nigra

TLDR
Analysis of products of oxidation and deamination of all four DNA bases in control and PD brains showed that levels of 8‐hydroxyguanine (8‐OHG) tended to be elevated and levels of 2,6‐diamino‐4‐Hydroxy‐5‐formamidopyrimidine (FAPy guanine) tendedto be decreased in PD, but the most striking difference was a rise in 8‐ OHG in PD substantia nigra.

Oxidative DNA damage accumulation in gastric carcinogenesis

TLDR
Chronic gastritis is characterised by the accumulation of oxidative DNA damage with mutagenic and carcinogenic potential, and H pylori infection is the major determinant for DNA adduct formation.

Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases.

TLDR
There was increased genomic DNA damage, and increased susceptibility to cytotoxic killing by hydrogen peroxide, in lymphocytes from patients with certain autoimmune diseases, which might be explained by defective repair of DNA damage or by increased production of reactive oxygen intermediates in inflammation.

In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients.

TLDR
Two major oxidative DNA lesions, 8-oxoguanine and thymine glycol, are excised from DNA in vitro by the same enzyme system responsible for removing pyrimidine dimers and other bulky DNA adducts, suggesting that XP neurological disease may be caused by defective repair of lesions produced in nerve cells by reactive oxygen species generated as by-products of an active oxidative metabolism.
...