Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis

  title={Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis},
  author={Y. Raza and Adnan Khan and A. Farooqui and M. Mubarak and Alex Facista and Syed Shakeel Akhtar and Saeed Khan and J. Kazi and C. Bernstein and S. Kazmi},
  journal={Pathology & Oncology Research},
  • Y. Raza, Adnan Khan, +7 authors S. Kazmi
  • Published 2014
  • Medicine
  • Pathology & Oncology Research
  • Helicobacter pylori infection is an established risk factor for gastritis, gastric ulcer, peptic ulcer and gastric cancer. CagA +ve H. pylori has been associated with oxidative DNA damage of gastric mucosa but their combined role in the development of gastric cancer is still unknown. Here we compare the combined expression of cagA and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in normal, gastritis and gastric cancer tissues. Two hundred gastric biopsies from patients with dyspeptic symptoms, 70… CONTINUE READING
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