Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis

@article{Raza2014OxidativeDD,
  title={Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis},
  author={Yasir Raza and Adnan Khan and Amber Farooqui and Muhammad Mubarak and Alexander Facista and Syed Shakeel Akhtar and Saeed M. Khan and Javed Iqbal Kazi and Carol Bernstein and Shahana Urooj Kazmi},
  journal={Pathology \& Oncology Research},
  year={2014},
  volume={20},
  pages={839-846}
}
Helicobacter pylori infection is an established risk factor for gastritis, gastric ulcer, peptic ulcer and gastric cancer. CagA +ve H. pylori has been associated with oxidative DNA damage of gastric mucosa but their combined role in the development of gastric cancer is still unknown. Here we compare the combined expression of cagA and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in normal, gastritis and gastric cancer tissues. Two hundred gastric biopsies from patients with dyspeptic symptoms, 70… 

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