Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis

@article{Raza2014OxidativeDD,
  title={Oxidative DNA Damage as a Potential Early Biomarker of Helicobacter pylori Associated Carcinogenesis},
  author={Y. Raza and Adnan Khan and A. Farooqui and M. Mubarak and Alexander Facista and Syed Shakeel Akhtar and Saeed M. Khan and J. Kazi and C. Bernstein and S. Kazmi},
  journal={Pathology \& Oncology Research},
  year={2014},
  volume={20},
  pages={839-846}
}
Helicobacter pylori infection is an established risk factor for gastritis, gastric ulcer, peptic ulcer and gastric cancer. CagA +ve H. pylori has been associated with oxidative DNA damage of gastric mucosa but their combined role in the development of gastric cancer is still unknown. Here we compare the combined expression of cagA and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in normal, gastritis and gastric cancer tissues. Two hundred gastric biopsies from patients with dyspeptic symptoms, 70… Expand
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References

SHOWING 1-10 OF 42 REFERENCES
Role of Helicobacter pylori CagA + Infection in Determining Oxidative DNA Damage in Gastric Mucosa
TLDR
A significant correlation was found between ROS production and 8-OHdG content, which could support the hypothesis that the oxygen-free radicalsmediated damage due to H. pylori cytotoxic strains could be a driving force that leads from chronic gastritis to gastric carcinoma. Expand
Influence of Helicobacter pylori on reactive oxygen-induced gastric epithelial cell injury.
TLDR
Alteration in the activity of ROS-scavenging enzymes by the presence of H. pylori may in part be responsible for the increased risk of gastric cancer in persons infected with H.pylori. Expand
Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa.
TLDR
Gastric mucosa of patients infected byHP-CagA-positive strains is characterized by a higher generation of ROMs and by greater neutrophil counts than that observed in HP-CAGA-negative subjects, which might be relevant in the pathogenesis of gastric malignancies. Expand
Helicobacter pylori, inflammation, oxidative damage and gastric cancer: a morphological, biological and molecular pathway
  • F. Farinati, R. Cardin, +5 authors M. Rugge
  • Biology, Medicine
  • European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation
  • 2008
TLDR
It is best to monitor patients harboring NiN closely with endoscopy and extensive bioptic sampling, and to eradicate any H. pylori to prevent the accumulation of oxidative DNA damage and its consequent progression, as the growing body of evidence of the regression of precancerous changes and the high prevalence of superficial gastric carcinoma demonstrated in long-term follow-up studies on NiN make this approach mandatory. Expand
Detection of Helicobacter pylori in gastric biopsy and resection specimens.
TLDR
Investigation of the sensitivity of detecting Helicobacter pylori in gastric biopsy and resection specimens using tinctorial and silver impregnation stains, immunohistochemistry and the polymerase chain reaction found it to be highly sensitive and easy to use. Expand
Helicobacter pylori infection in gastric cancerogenesis.
TLDR
This overview attempts to summarize the recent basic and clinical evidence on the link between H. pylori and gastric cancer, after the award of the Nobel Prize for Physiology or Medicine to Drs. Expand
Helicobacter pylori infection and gastric cancer risk: evaluation of 15 H. pylori proteins determined by novel multiplex serology.
TLDR
GroEL was identified as a new independent risk marker that may contribute to enhanced quantification of H. pylori-related GC risk and CagA and GroEL were found to be independent predictors of GC. Expand
Helicobacter pylori and gastric carcinogenesis
TLDR
The oncogenic potential of CagA may be further potentiated in the presence of chronic inflammation, which aberrantly induces activation-induced cytidine deaminase (AID), a member of the DNA/RNA-editing enzyme family. Expand
Helicobacter pylori cagA and vacA Genotypes as Predictors of Progression of Gastric Preneoplastic Lesions: A Long-Term Follow-Up in a High-Risk Area in Spain
TLDR
H. pylori genotyping may be useful for the identification of patients at high risk of progression of gastric preneoplastic lesions and who need more intensive surveillance. Expand
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk
TLDR
The host immune response is discussed and other host factors that increase the pathogenic potential of this bacterium are examined, including host polymorphisms, alterations to the apical-junctional complex, and the effects of environmental factors. Expand
...
1
2
3
4
5
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