Oxidative DNA Damage and Apoptosis Induced by Aclarubicin, an Anthracycline: Role of Hydrogen Peroxide and Copper

  title={Oxidative DNA Damage and Apoptosis Induced by Aclarubicin, an Anthracycline: Role of Hydrogen Peroxide and Copper},
  author={Hideki Mizutani and Yuka Hayashi and Miyabi Hashimoto and Masanori Imai and Yoshimi Ichimaru and Yuki Kitamura and Kenji Ikemura and Daisuke Miyazawa and Kin-ya Ohta and Yoshiaki Ikeda and Tohru Maeda and Masae Yoshikawa and Yusuke Hiraku and Shosuke Kawanishi},
  journal={AntiCancer Research},
  pages={3443 - 3451}
Background/Aim: This study aimed to investigate aclarubicin (ACR)-induced oxidative DNA damage and apoptosis. Materials and Methods: ACR-induced apoptosis was analyzed using HL-60 leukemia cells and HP100 cells, hydrogen peroxide (H2O2)-resistant cells derived from HL-60 cells. ACR-induced DNA damage was analyzed using plasmid DNA. Results: HL-60 cells were more sensitive to ACR than HP100 cells. In HP100 cells, DNA ladder formation and caspase-3/7 activity induced by ACR were suppressed or… Expand
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