Oxidative DNA Damage Induced by Pirarubicin, an Anthracycline Anticancer Agent, in the Presence of Copper(II).

  title={Oxidative DNA Damage Induced by Pirarubicin, an Anthracycline Anticancer Agent, in the Presence of Copper(II).},
  author={Hideki Mizutani and Ayano Nishimoto and Saki Hotta and Kenji Ikemura and Masanori Imai and Daisuke Miyazawa and Kin-ya Ohta and Yoshiaki Ikeda and Tohru Maeda and Masae Yoshikawa and Yusuke Hiraku and Shosuke Kawanishi},
  journal={Anticancer research},
  volume={38 5},
BACKGROUND/AIM One mechanism of the anticancer action of anthracyclines is believed to be oxidative DNA damage. Previously, we reported that doxorubicin induced oxidative DNA damage in the presence of Cu(II). However, the mechanism of pirarubicin-induced oxidative DNA damage has not been well clarified. MATERIALS AND METHODS DNA damage by pirarubicin in the presence of Cu(II) was analyzed using pBR322 plasmid DNA. O2•- derived from pirarubicin in the presence of Cu(II) was detected by… Expand
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