Oxidative Asymmetric [2 + 3] Annulation of Aldehydes with Azomethine Imines Enabled by N-Heterocyclic Carbene Catalysis.

Abstract

An efficient asymmetric [2 + 3] annulation of simple aldehydes with N,N'-cyclic azomethine imines via oxidative N-heterocyclic carbene (NHC) catalysis is disclosed, affording bicyclic pyrazolidinones bearing two vicinal tertiary stereogenic centers with moderate to good yields (56-84% for 19 examples), good to excellent diastereoselectivities (>20:1 for 17… (More)
DOI: 10.1021/acs.orglett.7b02948

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Cite this paper

@article{Yuan2017OxidativeA, title={Oxidative Asymmetric [2 + 3] Annulation of Aldehydes with Azomethine Imines Enabled by N-Heterocyclic Carbene Catalysis.}, author={Shiru Yuan and YuChen Luo and Jingyi Peng and Maozhong Miao and Jianfeng Xu and Hongjun Ren}, journal={Organic letters}, year={2017}, volume={19 22}, pages={6100-6103} }