Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.

@article{Soini2006OxidativenitrosativeSA,
  title={Oxidative/nitrosative stress and peroxiredoxin 2 are associated with grade and prognosis of human renal carcinoma.},
  author={Ylermi M Soini and Janne P. Kallio and Pasi Hirvikoski and Heikki Helin and Pirkko-Liisa Kellokumpu-Lehtinen and Sang Won Kang and Teuvo L. J. Tammela and Mirva Peltoniemi and Paula M Martikainen and Vuokko L. Kinnula},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={2006},
  volume={114 5},
  pages={329-37}
}
Peroxiredoxins (Prxs) 1-6 were assessed in 138 renal cell carcinomas (RCC) using immunohistochemistry and selected samples by Western blotting analysis. Oxidative/nitrosative damage was evaluated using nitrotyrosine immunoreactivity. The expressions of Prxs were correlated with tumor grade and survival and nitrotyrosine reactivity. Non-malignant kidney tubular cells showed positivity with variable intensity for all six Prxs. In RCCs, most cases were positive for Prxs 1 and 2, while only 15-20… CONTINUE READING

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