Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain

@inproceedings{Szalay2015OxidativeNitrativeSA,
  title={Oxidative/Nitrative Stress and Inflammation Drive Progression of Doxorubicin-Induced Renal Fibrosis in Rats as Revealed by Comparing a Normal and a Fibrosis-Resistant Rat Strain},
  author={Csaba Imre Szalay and Katalin Erdėlyi and G{\'a}bor K{\"o}k{\'e}ny and Enikő Lajt{\'a}r and M{\'a}ria God{\'o} and Csaba R{\'e}v{\'e}sz and Tam{\'a}s Kaucs{\'a}r and Norbert Kiss and M{\'a}rta Julianna S{\'a}rk{\"o}zy and Tam{\aa}s Csont and Tibor Kr{\`e}nacs and G{\'a}bor Sz{\'e}n{\'a}si and P{\'a}l Pacher and P{\'e}ter Hamar and Jaap A. Joles},
  booktitle={PloS one},
  year={2015}
}
Chronic renal fibrosis is the final common pathway of end stage renal disease caused by glomerular or tubular pathologies. Genetic background has a strong influence on the progression of chronic renal fibrosis. We recently found that Rowett black hooded rats were resistant to renal fibrosis. We aimed to investigate the role of sustained inflammation and oxidative/nitrative stress in renal fibrosis progression using this new model. Our previous data suggested the involvement of podocytes, thus… CONTINUE READING
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