• Chemistry, Medicine
  • Published in
    Journal of biochemical and…
    2015
  • DOI:10.1002/jbt.21695

Oxidative, metabolic, and apoptotic responses of Schwann cells to high glucose levels.

@article{Cinci2015OxidativeMA,
  title={Oxidative, metabolic, and apoptotic responses of Schwann cells to high glucose levels.},
  author={Lorenzo Cinci and Francesca Corti and Lorenzo di Cesare Mannelli and Laura Micheli and Matteo Zanardelli and Carla Ghelardini},
  journal={Journal of biochemical and molecular toxicology},
  year={2015},
  volume={29 6},
  pages={
          274-9
        }
}
The specific response of murine Schwann cells IMS32 to acute and chronic hyperglycemia conditions was evaluated. The pathophysiological alterations were studied to deepening the role of Schwann cells in diabetes-related neurotoxicity and to assess a model to screen new protective molecules. IMS32 were incubated with 30 and 56 mM glucose for 48 h and 7 and 14 days, and markers of oxidative stress, apoptosis, and polyol pathway were evaluated. High glucose induced O(2) -production and lipid… CONTINUE READING

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